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High Pure 98% Exemestane Anti Estrogen Steroids / Anti Estrogen Supplements CAS 107868-30-4

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High Pure 98% Exemestane Anti Estrogen Steroids / Anti Estrogen Supplements CAS 107868-30-4

China High Pure 98% Exemestane Anti Estrogen Steroids / Anti Estrogen Supplements CAS 107868-30-4 supplier
High Pure 98% Exemestane Anti Estrogen Steroids / Anti Estrogen Supplements CAS 107868-30-4 supplier High Pure 98% Exemestane Anti Estrogen Steroids / Anti Estrogen Supplements CAS 107868-30-4 supplier

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Product Details:

Place of Origin: China
Brand Name: Yuancheng
Certification: SGS ISO9001
Model Number: 107868-30-4

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Very discreet or as your requirement
Delivery Time: Within 24 hours after we confirm the payment
Payment Terms: T/T .Western Union . Bitcoin and MoneyGram
Supply Ability: 1000kg/week
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Detailed Product Description
Product Name: Exemestane CAS: 107868-30-4
Molecular Formula: C20H24O2 Molecular Weight: 296.4
Appearance: White Or White Crystalline Powder Origin: China

High Quality 98% ExemestaneAcatate (aromasin) (CAS: 107868-30-4) reasonable price

 

 

 

Basic Info

 

Product name: Exemestane


Other name: Aromasin


CAS Registry Number: 107868-30-4


Assay: 98%


Molecular Form

 

ula: C20H24O2


Molecular Weight: 296.4


Packing: 1kg/bag


Appearance: White or white crystalline powder


Usage: An antineoplastic (hormonal). Used to treat breast cancer with hormonal therapy. Aromatase inhibitors block the synthesis of estrogen


Using method: you should make exemestane into pills and 25mg/pill. you must use the exemestane pills after meal.


Function:

 

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.


The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain.

 

Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.


Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition."

 

By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.


The estrogen suppression rate for exemestane varies from 35% for estradiol (E2) to 70% for estrone (E1).


Clinical uses:


Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy. US FDA approval was in October 2005.


Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.


A Phase III trial has been reported which concluded that the use of exemestane in postmenopausal women at an increased risk for breast cancer reduced the incidence of invasive breast cancer.

 

In 4,560 women, after 35 months, the administration of exemestane at a dose of 25 mg/day resulted in a 65% reduction in the risk of breast cancer compared with placebo; annual incidence rates were 0.19% and 0.55%, respectively (hazard ratio: 0.35; 95% CI [0.18-0.70]; p = 0.002).


Therapeutic Efficacy:


Oral exemestane 25 mg/day for 2-3 years of adjuvant therapy was generally more effective than 5 years of continuous adjuvant tamoxifen in the treatment of postmenopausal women with early-stage estrogen receptor-positive/unknown receptor status breast in a large well-designed trial.

 

Preliminary data from the open-label TEAM trial comparing exemestane with tamoxifen indicates that exemestane 25 mg/day is also effective in the primary adjuvant treatment of early-stage breast cancer in postmenopausal women.


Interim phase III trial results in 2011 show that adding Afinitor (everolimus) to exemestane therapy against advanced breast cancer can significantly improve progression-free survival compared with exemestane therapy alone.

 

Our Services

 

1. Any Inquiries will be replied within 24 hours
2.Hight quality, fashion designs reasonable & competitive price. fast lead time.
3.Payment: You can pay for the order via: T/T, Western Union, MoneyGram&Bitcion
4. After Sale Service:
1).All products will have been strictly Quality Checked in house before packing.
2).All products will be well packed before shipping.
3)Parcel can be sent out in 24 hours after payment. Tracking number available
4)Secure and discreet shipment. Various transportation methods for your choice.
5)Customs pass rate ≥99%
6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
5. Shipping
we have strong cooperation with DHL, UPS, FEDEX, EMS, China Air PostYou also can choose your own shipping forwarder.

High Pure 98% Exemestane Anti Estrogen Steroids / Anti Estrogen Supplements CAS 107868-30-4

 

 

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