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Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Cancer

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Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Cancer

China Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Cancer supplier
Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Cancer supplier Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Cancer supplier

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Product Details:

Place of Origin: China
Brand Name: Yuancheng
Certification: SGS ISO9001
Model Number: 120511-73-1

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Very discreet or as your requirement
Delivery Time: Within 24 hours after we confirm the payment
Payment Terms: T/T .Western Union . Bitcoin and MoneyGram
Supply Ability: 1000kg/week
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Detailed Product Description
Product Name: Anastrozole CAS: 120511-73-1
Molecular Formula: C17H19N5 Molecular Weight: 293.37
Appearance: White To White Crystalline Powder Origin: China

Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Anti Cancer

 

Basic Info

 

Product name: Anastrozole


Synonym: ARIMIDEX


CAS Registry Number: 120511-73-1


Molecular Formula: C17H19N5


Molecular Weight: 293.37


Assay: 99%


Packing: 1kg/aluminum foil bag


Appearance: White to white crystalline powder


Usage: An aromatase inhibitor. Used as an antineoplastic raw materials.
Storage: shading, confined preservation

 

Anastrozole (INN) (marketed under the trade name Arimidex by AstraZeneca) is a non-steroidal aromatase-inhibiting drug approved for treatment ofbreast cancer after surgery, as well as for metastasis in both pre and post-menopausal women.

 

The severity of breast cancer can be increased byestrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen. The patent on Arimidex by AstraZeneca expired June 2010.

Arimidex Pharmaceutical Steroids Anti Estrogen Steroids Anastrozolesfor Cancer

 

Medical uses

 

The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial was an international randomised controlled trial of 9366 women with localized breast cancer who received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up.

 

After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group.

 

The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer, which is estrogen receptor (ER) positive.

 

Another study found that the risk of recurrence was reduced 40%, but was associated with an increased risk of bone fractures.

 

The study concluded that ER positive patients benefited from switching from tamoxifen to anastrozole in patients who have completed 2 years' adjuvant tamoxifen.

 

A more recent trial found that anastrozole significantly reduced the incidence of breast cancer in postmenopausal women relative to placebo, and while there were side effects related to estrogen deprivation observed, the researchers concluded that this was probably not related to the treatment.

 

Lead author Jack Cuzick was quoted by the BBC as saying, "This class of drugs is more effective than previous drugs such as tamoxifen and crucially, it has fewer side effects," adding that he thought there was now enough evidence to support offering the drug.

 

Mechanism of action

 

Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition, inhibits the conversion of androgens to estrogens in peripheraltissues (extra-gonadal).

 

Side effects

 

Bone weakness has been associated with anastrozole. Women who switched to anastrozole after two years on tamoxifen reported twice as many fractures as those who continued to take tamoxifen (2.1% compared to 1%).

 

Bisphosphonates are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors. The level of circulating estradiol is likely causal here and not the anastrozole itself, and so the dose will determine likelihood of osteoporosis (estradiol inhibits osteoclasts, which resorb bone).

 

Usage in men

 

Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia,gynecomastia, and symptoms of hypogonadism.

 

It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen--gynecomastia, emotional lability and water retention.

 

Study data suggests dosages of 0.5 mg to 1 mg a day reduce serum estradiol approx. 50% in men, which differs in postmenopausal women.

 

Usage in children

 

Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia.

 

Following the onset of puberty, theepiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system.

 

It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormonesfor the treatment of growth hormone deficiency.

 

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