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Synonyms: Trans-4-Aminomethylcyclohexane-1-carboxylate; Trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Amstat
EINECS No.: 212-818-4
M. F.: C8H15NO2
M. W.: 157.21
Apperance: White crystalline Powder
Type: Anesthetic Agents
Grade Standard: Cosmetic Grade, Medicine Grade
Chloride: 140ppm max
Loss on drying: 0.5%max
Sulfated ash: 0.1%max
Use: Hemostatic effect; (for pharmaceutical and cosmetic use)
Packing: 1kg Aluminum foil bag or 25kg fiber drum
Hemostatic, anti-allergic, anti-inflammatory effect
The development and fibrinolytic phenomena associated with the body heal under physiological or pathological state of fibrinolysis, increased vascular permeability, etc., but also on the body caused by reaction with fibrinolysis, a variety of symptoms and allergic reactions such as bleeding. This product can inhibit plasmin, and display bleeding, anti-allergic, anti-inflammatory effect.
The role of an anti-plasmin in Tranexamic acid can be combined with the plasmin and plasminogen and
fibrin affinity site lysine site (LBS) is strongly adsorbed by inhibition of plasmin, plasminogen and fibrin
binding and thus strongly inhibit fibrin by plasmin-induced decomposition; Addition, in the presence of
serum and other anti-plasmin macroglobulin, tranexamic acid antifibrinolytic effect is more obvious.
|Characteristics||White or almost white, crystalline powder||White crystalline powder|
|Melting point||More than 300 degree||Conforms|
|Identification||Infrared absorption atlas consistent with the contrast atlas||Conforms|
|Solubility||Soluble in water, practically insoluble in acetone and alcohol||Conforms|
|Clarity and color||Solution should clarify and colorless||Conforms|
|Impurity A: not more than 0.1%
Impurity B: not more than 0.2%
Impurity C: not more than 0.1%
Impurity D: not more than 0.1%
|Loss on drying||Not more than 0.5%||0.20%|
|Sulphate||Not more than 0. 07%||0.01%|
|Chloride||Not more than 140ppm||Less than 140ppm|
|Heavy Metals||Not more than 10ppm||Less than 10ppm|
|Residue on Ignition||Not more than 0.1%||0.02%|
Function of Aminomethylbenzoic Acid:
A- For fibrinolytic hemorrhages, such as brain, lung, uterine, the prostate gland, adrenal gland, thyroid gland, trauma or surgical bleeding.
B- Intraoperative early medication or preoperative medication, can reduce bleeding in the operation, and decrease the amount of blood transfusion.
C- Also used in pulmonary hemorrhage, liver cirrhosis hemorrhage and upper gastrointestinal hemorrhage.
D- Used in bleeding caused by fibrinolysis process hyperfunction:
Such as abnormal bleeding of operation for the lung, liver, pancreas, prostate, thyroid, adrenal surgery.
Such as obstetrics and postpartum hemorrhage and tuberculosis hemoptysis or blood-stained sputum, hematuria, prostatic hypertrophy bleeding, upper gastrointestinal bleeding, etc.
E- Can also be used for bleeding caused by excessive streptokinase or urokinase.
1. Hemostatic, significant effect on traumatic bleeding, preoperative prophylactic medication can decrease operation hemorrhage.
2. The chemical structure of tranexamic acid and lysine, competitive inhibition of plasminogen to fibrin adsorption, to prevent their activation, protect the fiber protein was not degraded by the enzyme and dissolved, ultimately achieve hemostasis effect.
3. All applicable in the treatment of acute or chronic, localized or systemic primary fibrinolysis hyperfunction caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hypertrophy of the prostate, hemophilia hemorrhage, pulmonary tuberculosis hemoptysis, bleeding in the stomach, liver, lung, spleen and other organs of hemorrhage after operation
4. The clinical effect of tranexamic acid on insect bites, eczema and dermatitis, simple purpura, chronic urticaria, artificial sex urticaria, rash and drug poisoning effect, also have certain effects on erythroderma, scleroderma, SLE, erythema multiforme, herpes zoster and alopecia areata, curative effect of hereditary angioedema is also good.