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|Assay:||98%||Appearance:||White Crystalline Powder|
Glucocorticoid Anti-Inflammatory Clobetasol Propionate CAS 25122-46-7
English Synonyms: 17-propionate;clobesol;pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,
Chemical Properties White Crystalline Powder
Usage: Adrenal cortical hormone and adrenocorticotropic hormone class medicine.For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
|Product Name||Clobetasol propionate|
|Product Categories:||Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceutical intermediate;TORADOL;Hormone Drugs|
|Usage||For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.|
Clobetasol Propionate is a highly potent topical steroid.It has both local anti inflammatory and immunosuppressive activity.Clobetasol, as the Propionate salt, is only used topically on the skin and its effects are limited to the local anti-inflammatory activity.
Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.
Clobetasol propionate is marketed and sold worldwide under numerous names including Clobex, Clob-x (Colombia),Clovate, Cormax (Watson, US), Pentasol (Colombia), Cosvate (India), Temovate (US), Dermovate (GlaxoSmithKline, Pakistan, Portugal, Israel), Olux, Tenovate, Dermatovate, Butavate, Movate, Novate, and Powercort.
This product is rapid, the current clinical application of effective topical cortico steroids medicine effect of a strong. Has the strong capillary contraction, the anti-inflammatory effects of hydrocortisone for 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. Systemic adverse reactions for 3 times fluocinolone, anhydrous sodium retention effect, have certain promote sodium, potassium excretion.
1, clobetasol propionate is a synthetic high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary vascular contraction, the anti-inflammatory effects of hydrocortisone is about 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. At the same time with inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.
2, external apply to chronic eczema, neurodermatitis, psoriasis and palmoplantar pustulosis, lichen planus, discoid lupus erythematosus, glucocorticoid, topical treatment of pruritic effective and non infectious inflammatory skin disease.
3, has the inhibitory effects of anti-inflammatory, anti allergic, anti proliferation, immune.Can compound products: ketoconazole. vitamin A acid cream and liniment.
Clobetasol propionate Specification:
|Appearance||White to cream, crystalline powder||White crystalline powder|
|Identification (by IR)||Conforms to the CRS spectrum||Conforms|
|Melting Point||Approximately 196 °C||196°C|
|Specific rotation||+98°~+104°(dried substance)||+99.7°|
|Loss on drying||≤2.0%||0.2%|
|Residue on ignition||≤0.1%||0.06%|
|Related substance (by HPLC)||Any impurity ≤1.0%||0.22%|
|Total impurities ≤2.0%||0.31%|
|Assay(by HPLC)||Contains 97.0% to 102% of C25H32CIFO5
|Residual solvents||Ethanol ≤3000ppm||262ppm|
|Conclusion||Meet the specification according to USP35|