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|Molecular Formula:||C10H13NO2||Molecular Weight:||179.22|
|EINECS:||200-533-0||Packing:||25kg Board Barrel|
pharma raw materials,
Chinese synonyms: phenacetin; acetyl Sulfanilic; acetyl ethoxy aniline; acetyl ethoxy aniline; p-acetaminophenyl; phenacetin; acetophenetidine; 4- ethoxy acetyl aniline
English Name: Phenacetin
English synonyms: 1-ACETYL-P-PHENETIDIN; 4-ACETOPHENETIDIDE; 4-acetophenetidine; 4'-ETHOXYACETANILIDE; 4-ETHOXYACETANILIDE; ACETOPHENETIDIN; ACETOPHENETIDINE; ACET-P-PHENETIDINE
CAS number: 62-44-2
Molecular formula: C10H13NO2
Molecular weight: 179.22
EINECS number: 200-533-0
Packing: 25kg board barrel
Keywords: phenacetin, raw material medicine
Quality standard: the national standard
Related categories: Organics; pharmaceutical and bio chemical; API; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; other
Chemical properties: white scaly crystal gloss or white crystalline powder. The melting point of 137-138 deg.c, refractive index 1.571. Insoluble in water, slightly soluble in, slightly soluble in water, soluble in ethanol and chloroform. Soluble in concentrated sulfuric acid is not significant to the solution color, drip into the nitric acid is orange yellow. Odorless, slightly bitter taste.
Antipyretic analgesics for the treatment of fever, headache, neuralgia, etc..
1, antipyretic and analgesic, antipyretic and analgesic effects of phenacetin and acetylsalicylic acid "similar, mainly used as antipyretic analgesics, slow action and lasting, have better curative effect on the treatment of headache, neuralgia, arthritis pain and fever, but anti rheumatism and anti-inflammatory effect is weak. Overdose can cause methemoglobinemia, caused by hypoxia, long-term use can damage the kidneys, and even cause papillary necrosis, should be used with caution. Due to the rapid development of its toxic side effects and other similar drugs, the drug has been stopped used alone, just as the raw material medicine and other drugs with compound preparation. Often associated with aspirin, caffeine together form a compound aspirin, which is composed of phenacetin 0.162 grams, 0.227 grams of aspirin, caffeine and 0.035 grams, lower toxicity, for the treatment of colds. Such as adding the drug in a small number of chlorpheniramine, also can be made into chlorpheniramine cold tablets, can be used for the treatment of cold headache, neuralgia, rheumatism pain.
2, phenacetin itself has no antipyretic analgesic effect in the body through the metabolism, decomposition of acetaminophen is paracetamol, just play the antipyretic and analgesic effect. Also the decomposition of ammonia benzene, not only no antipyretic analgesic effect on ammonia benzene, and is a major factor of non toxic and side effect of phenacetin. In 1954 China began production of phenacetin, etherification reaction of nitrobenzene by nitro chlorobenzene and ethanol, and then restore the pairwise amino benzene with acetic acid prepared by acetylation reaction. Side effects of long-term use of preparations containing phenacetin, can cause renal papillary necrosis, interstitial nephritis, and may even induce carcinoma of renal pelvis and bladder cancer. Phenacetin is also easy to make the formation of methemoglobin to hemoglobin, blood oxygen carrying capacity decreased, causing cyanosis reaction. In addition, phenacetin can also cause hemolysis and hemolytic anemia, and has a certain toxicity to the retina. The long-term use of phenacetin, can also cause dependence on drugs. Foreign countries such as America, Britain, Germany, Japan and other countries have decided to cancel the phenacetin, or provisions in its packaging must be marked "not for long term use and large doses of".
1, phenacetin through in use of paracetamol and ethyl iodide in the presence of anhydrous potassium carbonate reflux, the occurrence of Williamson synthesis. The crude product recrystallized in water purification.
2, by aminobenzene by acetylation and.
Benzene, acetic anhydride and p-amino benzene mixture in the oil bath heating azeotropic 4h, after cooling response of reactants, namely non Nating precipitation, filtering, cold benzene washing, drying to obtain the theory amount 86%, yield.